5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER

5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER - Names and Identifiers

Name	Methyl 5-fluoro-2-hydroxybenzoate
Synonyms	METHYL 5-FLUORO-2-HYDROXYBENZOATE Methyl 5-fluoro-2-hydroxybenzoate 4-Fluoro-2-(methoxycarbonyl)phenol 5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER 4-Fluoro-2-(methoxycarbonyl)phenol, Methyl 5-fluorosalicylate
CAS	391-92-4
InChI	InChI=1/C8H7FO3/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4,10H,1H3

5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER - Physico-chemical Properties

Molecular Formula	C8H7FO3
Molar Mass	170.14
Density	1.309±0.06 g/cm3(Predicted)
Melting Point	30-34
Boling Point	50/0.15mm
Flash Point	105
Vapor Presure	0.0265mmHg at 25°C
Appearance	Low Melting Solid
Color	Pale yellow
pKa	9.77±0.18(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.526

5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
HS Code	29182900
Hazard Note	Irritant

5-FLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER - Reference Information

Application

Methyl 5-fluoro-2-hydroxybenzoate is an organic intermediate, which can be obtained by esterification of 5-fluorosalicylic acid and methanol. The esterification method can be sulfuric acid dehydration or 5-fluorosalicylic acid is first made into acid chloride and then acylated.

preparation

at 0 ℃, slowly add concentrated sulfuric acid (20mL) to the stirring solution of 5-fluorosalicylic acid (25g,160mmol) in MeOH(250mL). The resulting reaction mixture was refluxed for 48h, then concentrated under reduced pressure and the resulting crude was alkalized with saturated NaHCO3 to pH 8.0. The mixture was neutralized with a 1.5N HCl solution and extracted with EtOAc. The organic layer was dried with anhydrous Na2SO4 and concentrated to give methyl 5-fluoro-2-hydroxybenzoate as a light brown liquid (22.8g,83% yield).

Last Update：2024-04-09 20:49:11